- Caliber: .25-06 Remington
- Bullet Weight: 120 grain
- Bullet Style: PSP Core-Lokt®
- Muzzle Velocity: 2,990 FPS
- Muzzle Energy: 2,382 ft.-lbs.
- Case Type: Brass
- Primer Type: Boxer, reloadable
- Corrosive: No
The cartridge is capable of propelling a 117 grain (7.6 g) bullet at up to 3,200 feet per second (980 m/s) and energy levels up to 2,500 ft⋅lbf (3,400 J). Bullets lighter than 75 grains are available in .257 caliber, but were designed for the smaller .25-20 Winchester and .25-35 Winchester cartridges and are too lightly constructed for the high velocities of the .25-06.
The cartridge has less felt recoil than a .30-06 in a similar weight rifle, due to the lighter weight bullets used. Shooters who are recoil sensitive will find the recoil from the .25-06 bearable, but not pleasant enough to shoot all day long. This cartridge is not quite as powerful as the .257 Weatherby Magnum, usually running 200–300 ft/s (61–91 m/s) slower with a given bullet weight.